品牌：為華生物

產(chǎn)地：中國(guó)廣州

CAS號(hào)1069-79-0

PEG分子量：2k、3.4k、5k

外觀：白色至淡白色固體粉末。

常用溶劑：Water（水）、Methanol（甲醇）、Chloroform（三氯甲烷）、?DMF、DMSO

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2-Distearoyl-sn-Glycero-3-Phosphoethanolamine(DSPE)共軛聚乙二醇是磷脂和聚乙二醇結(jié)合具有親水性和疏水性。聚乙二醇磷脂脂質(zhì)體形成材料,可用于藥用輔料；輸送、基因轉(zhuǎn)染和疫苗傳遞。具有乳化、藥物增容的作用，近年來(lái)脂質(zhì)體、脂肪乳、納米粒等緩控釋藥物制劑的重要材料。聚乙二醇化磷脂能顯著改善血液循環(huán)時(shí)間和穩(wěn)定封裝藥物。對(duì)磷脂分子進(jìn)行修飾，也具備使制劑在特定條件下釋放和靶向定位的能力。

通常修飾的方式有

1、引入聚合物改善制劑的血循環(huán)時(shí)間、崩解時(shí)間

2、引入免疫因子增強(qiáng)靶向性

3、引入標(biāo)記物用以診斷和追蹤

PEG聚乙二醇是常用于改善磷脂性能的一種聚合物，末端可以進(jìn)一步修飾，用來(lái)連接多肽、抗體、核酸等等，使得PEG磷脂載體具有免疫靶向性，這一類磷脂就稱之為功能化PEG磷脂

(DSPE)conjugated polyethylene glycol is a combination of phospholipid and polyethylene glycol with hydrophilicity and hydrophobicity. Polyethylene glycol phospholipid liposome forming material can be used as pharmaceutical excipients; Delivery, gene transfection and vaccine delivery. It has the function of emulsification and drug compatibilization. In recent years, it is an important material for slow-release and controlled-release drug preparations such as liposomes, fat emulsions and nanoparticles. Pegylated phospholipids can significantly improve blood circulation time and stably encapsulate drugs. The modification of phospholipid molecules also has the ability to release and target the preparation under specific conditions.

The usual ways of modification are:

1. The introduction of polymer improves the blood circulation time and disintegration time of the preparation

2. Introduction of immune factors to enhance targeting

3. Introduction of markers for diagnosis and tracking

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Peg polyethylene glycol is a polymer commonly used to improve the performance of phospholipids. The end can be further modified to connect polypeptides, antibodies, nucleic acids, etc., so that PEG phospholipid carriers have immune targeting. This kind of phospholipids is called functionalized peg phospholipids