環(huán)巴胺(Cyclopamine)從藜蘆屬植物內(nèi)分離得到的一種異甾體類生物堿，主要存在百合科植物中北美山藜蘆(Veratrum californicum)、印第安鹿食草(Corn lily)及毛葉藜蘆(Veratrum grandiflorum)、伊貝(Fritillaria pallidiflora Schrenk)四種植物。

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環(huán)巴胺對Hedgehog信號通路有抑制作用,在抗腫瘤方面表現(xiàn)出良好的活性。研究表明，環(huán)巴胺可以對Hedgehog信號通路的激活起到抑制作用，而后者參與原癌基因?Smoothened (Smo)?或滅活腫瘤抑制基因?Patched (Ptch)?的突變相關反應途徑，并且這兩種基因都能夠編碼多程跨膜蛋白。此外，已經(jīng)證明環(huán)巴胺的抑制作用是由于其與Smo七螺旋蛋白束的直接結合有關。

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艾美捷丨LC Laboratories?環(huán)巴胺?/ Cyclopamine?目前已經(jīng)應用到quan球4100個實驗室，純度非常高，當然價格也是十分友好的。

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環(huán)巴胺?/ Cyclopamine?其它基本參數(shù)：

cat#?LCL-C-8700

規(guī)格?10mg/25mg/100mg/300mg

CAS號?4449-51-8

分子式?C27H41NO2

分子量?411.62

純度?＞99%

外觀?白色結晶固體；或小瓶底部透明固體膜

溶解性?溶于乙醇或DMSO

運輸與保存方法?常溫運輸；-20℃保存

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Nature communications正文引用：

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其他參考文獻

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[1]. Peukert S, et al. Identification and structure-activity relationships of ortho-biphenyl carboxamides as potent Smoothened antagonists inhibiting the Hedgehog Signaling pathway. Bioorg Med Chem Lett, 2009, 19(2), 328-331.

[2]. Berman DM, et al. Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature, 2003, 425(6960), 846-851.

[3]. Thayer SP, et al. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature, 2003, 425(6960), 851-856.

[4]. Ma W, et al. Reduced Smoothened level rescued Aβ-induced memory deficits and neuronal inflammation in animal models of Alzheimer's disease. J Genet Genomics. 2018 May 20;45(5):237-246.

[5]. Qi Wan, et al. Overexpression of Laminin?α4 Facilitates Proliferation and Migration of Fibroblasts in Knee Arthrofibrosis by Targeting Canonical Shh/Gli1 Signaling. Connect Tissue Res. 2020 May 24.