海沙瑞林/Hexarelin是一種生長(zhǎng)激素促分泌劑，最近被證明通過(guò)CD36受體對(duì)脂肪代謝具有有益的作用。在這項(xiàng)研究中，Hexarelin顯著改善了MKR小鼠的葡萄糖和胰島素不耐受，并降低了血漿和肝臟甘油三酯。這些有益的代謝效應(yīng)可能是由于六肽海沙瑞林/Hexarelin改善了脂肪代謝，并增強(qiáng)了白色脂肪組織的脂肪細(xì)胞分化。

海沙瑞林/Hexarelin可能對(duì)脂肪代謝產(chǎn)生有益影響。Rodrigue-Way等人的研究表明，海沙瑞林/Hexarelin可能與B類(lèi)清道夫受體結(jié)合，以增強(qiáng)巨噬細(xì)胞和脂肪細(xì)胞中過(guò)氧化物酶體增殖物激活受體γ（PPAR-γ）的激活。

Hexarelin，GHRP-6的修飾衍生物，其結(jié)構(gòu)如下：His-2-Me-D-Trp-Ala-Trp-D-Phe-Lys-NH2。

Our data show that the PRL ?releasing effect of hexarelin is preserved in acromegaly but lost in ?pathological hyperprolactinaemia. In contrast with acromegaly, the GH ?releasing effect of hexarelin is also blunted in hyperprolactinaemic ?patients. These data demonstrate that patients with pathological ?hyperprolactinaemia are partially refractory to the activity of ?hexarelin.